Biofil™ Plus

Double Layer Polyethersulphone Membrane Cartridge Filters

The Porvair Filtration Group Biofil™ Plus microbial rated cartridge has been developed and manufactured for the filtration of liquids in the pharmaceutical, biotechnology and other critical applications. Biofil™ Plus utilises a naturally hydrophilic polyethersulphone (PES) membrane with a mirrored asymmetric pore structure. The cartridge’s unique built in prefiltration membrane layer provides longer life and higher throughput.

Features and Benefits

  • Guaranteed microbial ratings
    Biofil™ Plus cartridges are validated for bacterial removal according to HIMA guidelines and ASTM F838-05, with a log reduction value >7. They are therefore suitable for applications requiring sterilising grade filtration.
  • Low protein binding
    Biofil™ Plus cartridges have excellent low protein binding characteristics, typically 10 times lower than nylon, 2 times lower than polysulphone and similar to PVDF.
  • Will not hydrolyse
  • Excellent chemical compatibility
  • Cartridge integrity and low TOC levels
    Each Biofil™ Plus module of every cartridge is individually integrity tested. Each complete filter cartridge is flushed with pure water which is inspected daily for pyrogens using the standard LAL test. When required, they can be pulse flushed with 18MΩ.cm pyrogen-free ultra-clean water.
  • Suitable for steam sterilising
    Biofil™ Plus cartridges incorporating a stainless steel support ring can be subjected to steam sterilisation at 125°C (257°F) without loss of integrity.

Materials of Manufacture

Prefilter membrane: Polyethersulphone
Final membrane: Polyethersulphone
Membrane support: Polypropylene
Irrigation mesh (support): Polypropylene
Drainage layer: Polypropylene
Inner core: Polypropylene
Outer support: Polypropylene
End fittings: Polypropylene
Support ring: Stainless steel

Gaskets and O-Rings

FDA approved Ethylene Propylene, PTFE encapsulated, Silicone or Nitrile.

Maximum Differential Pressure

Normal flow direction at:
20°C (68°F): 6.0bar (87psi)
80°C (176°F): 4.0bar (58psi)
100°C (212°F): 3.0bar (43psi)
120°C (248°F): 2.0bar (29psi)

Integrity Testing

Each Biofil™ Plus module of every cartridge is individually integrity tested using the Diffusive Flow Test, which correlates to the HIMA and ASTM F838-05 bacterial challenge tests. Non-destructive integrity tests, such as Pressure Hold, Diffusive Flow and Bubble Point, can be performed by customers. Procedural details are available from Porvair.

Effective Filtration Area

Pore Size Rating Effective Filtration Area (each 254mm (10") module)
0.2, 0.45 and 0.65μm 0.48m2 (5.2ft2)

Operating Temperature

Maximum continuous: 60°C (140°F)


  • Biopharmaceuticals
    For the sterilisation of biological fluids, cell culture media, sera and blood fractionations.
  • Fermentation
    For providing sterile feed stock for the production of antibiotics and enzymes.
  • Opthalmic solutions
  • API’s
    For the clarification and sterilisation of a wide range of active pharmaceutical ingredients.
  • LVP’s
    For final filtration of Total Nutritional Fluids, dextrose, amino acids and saline solutions.
  • Beverages

Clean Water Flow Rates


RR Retention Rating
MT Maximum temperature recommended of a working product in degrees centigrade
MoC Primary material of construction
MoC Primary material of construction
MP Maximum working pressure of housing in bar
Brand Manufacturing brand name supplying the product
FE Filter efficiency
Q Quality assurances and certificates validating this product